Low vitamin B 6 in patients with acute myocardial infarction

Abstract

The vitamin B 6 status of 84 patiente with acute myocardial infarction was compared with that of 84 control subjects. Pyridoxal and pyridoxal 5′-phosphate (PLP) in plasma and erythrocytes, as well as the basal and total potential activity of the PLP-dependent enzyme aspartate aminotransferase in erythrocytes, were measured for a comprehensive assessment of vitamin B 6 status. The mean levels of all vitamin B 6 indexes (except pyridoxal) were lower in the patients than in the control subjects. The differences were statistically significant, except for erythrocyte PLP and total potential enzyme activity. The adjusted relative odds of a myocardial infarction for subjects in the lowest quartile ef plasma PLF was about 5 times higher when compared with those in the highest quartile (relative odds = 5.2, 95% confidence interval = 1.4 to 18.9). Similar findings were found with the other vitamin E 6 indexes. No significant association between infarct size, as estimated by creatine kinase level, and the vitamin B 6 indexes was observed.