Abstract
Guidelines recommend venous thromboembolism (VTE) prophylaxis in hospitalized medical patients with Padua prediction score (PPS) ≥4 points. This recommendation is based on the high risk of symptomatic VTE observed among these patients in the Italian PPS derivation study, and the fivefold risk reduction with VTE-prophylaxis. This study aims to assess the incidence of VTE in high risk medical patients in a medium sized hospital in Israel. In this retrospective cohort study, data was collected of all medical patients hospitalized between January and June 2014. Patients were classified into low and high risk groups according to their PPS score, and according to whether they received anticoagulant thromboprophylaxis for VTE. Patients were further randomly selected to compare high risk patients that did or did not receive anticoagulant thromboprophylaxis. We further compared VTE incidence in high and low risk patients not treated with thromboprophylaxis. A search was conducted for diagnoses of venous thromboembolism and death during hospitalization and the following 90 days. 568 high risk patients (PPS ≥4 points) were included, 284 treated with prophylactic anticoagulation and 284 not. There were no VTE events in either group. There was no difference in mortality. A total of 642 non anticoagulated patients were randomly selected, 474 low risk and 168 high risk. There were no VTE events in either group. The risk of VTE appears to be very low in our study, suggesting that among medical patients with PPS ≥4, the risk of VTE may differ dramatically between populations.
Highlights
Venous Thromboembolism (VTE) is defined as deep vein thrombosis (DVT) or pulmonary embolism or both, and is associated with increased mortality and complications such as, postthrombotic syndrome, increased risk for recurrence of thrombosis and development of pulmonary hypertension [1].In the past, only surgical patients were considered at risk for developing VTE [2]
The risk of VTE appears to be very low in our study, suggesting that among medical patients with Padua Prediction Score (PPS) 4, the risk of VTE may differ dramatically between populations
Over the past few decades it has become apparent that hospitalized patients have an increased risk of developing VTE [3,4,5,6,7,8] and VTE prophylaxis confers a strong benefit in a selected high risk group of medical patients [9,10,11,12,13,14,15]
Summary
Venous Thromboembolism (VTE) is defined as deep vein thrombosis (DVT) or pulmonary embolism or both, and is associated with increased mortality and complications such as, postthrombotic syndrome, increased risk for recurrence of thrombosis and development of pulmonary hypertension [1].In the past, only surgical patients were considered at risk for developing VTE [2]. Over the past few decades it has become apparent that hospitalized patients have an increased risk of developing VTE [3,4,5,6,7,8] and VTE prophylaxis confers a strong benefit in a selected high risk group of medical patients [9,10,11,12,13,14,15]. Guidelines recommend venous thromboembolism (VTE) prophylaxis in hospitalized medical patients with Padua prediction score (PPS) 4 points. This recommendation is based on the high risk of symptomatic VTE observed among these patients in the Italian PPS derivation study, and the fivefold risk reduction with VTE-prophylaxis.
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