Low-tube-voltage combined with adaptive statistical iterative reconstruction-V technique in CT venography of lower limb deep vein thrombosis

Dan Chen,Min Xu,Xinnan Li,Jiahui Zhou,Wei Qiu,Peixi Wang,Quanxu Ge,Xiaodong Wang

doi:10.1038/s41598-018-29519-y

Dan Chen, Min Xu + Show 6 more

Open Access

https://doi.org/10.1038/s41598-018-29519-y

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Journal: Scientific Reports	Publication Date: Jul 24, 2018
Citations: 7	License type: open-access

Affiliation: Weihai Municipal Hospital

Abstract

This study contains 2 arms: (1) the ASIR-V technique combined with low-tube-voltage in lower limb deep vein thrombosis (DVT) diagnosis was investigated; and (2) CT venography and ultrasound results in DVT diagnosis were compared. For arm 1, 90 patients suspected of DVT were randomly divided into 3 groups (30/group): groups A and B were scanned under 100-kV with pre-set ASIR-V weights of 30% and 50% respectively; group C were scanned under 70-kV with a 50% weight. For arm 2, 75 patients were divided into 3 groups (25/group), each group was CT scanned as in arm 1 and then all subjects were examined by ultrasound. Groups A, B and C had 16, 14 and 17 patients diagnosed with DVTs, respectively. There was no significant difference in subjective ratings of image quality among all groups. The 70-kV protocol remarkably increased venous attenuation value while all groups had similar DVT attenuation value. Higher noise was observed in group C, the CNR however, was actually augmented due to elevated venous attenuations. More importantly, group C had significantly lower CTDIvol and DLP values. In conclusion, the 70-kV protocol is superior to the 100 kV protocols, which was supported by findings from the second arm study.

Highlights

Deep vein thrombosis (DVT), the formation of blood thrombi in the deep veins, remains a common and serious clinical condition worldwide
This study was conducted to compare the impacts of 70 kV and 100 kV combined with adaptive statistical iterative reconstruction (ASIR)-V technique in computed tomography (CT) venography of lower limb deep vein thrombosis (DVT)
Groups A, B and C had 16, 14 and 17 patients diagnosed with DVT by CT venography, respectively (The diagnosis of DVT was made after clots were identified in CT images, see Fig. 1)

Summary

Introduction

Deep vein thrombosis (DVT), the formation of blood thrombi in the deep veins, remains a common and serious clinical condition worldwide. It often manifests as DVT in the lower extremity, but may occur in veins of other body parts, e.g., in cerebral sinus, arms, retina, etc[1,2]. As DVT is often asymptomatic and its clinical features are unspecific, to date, diagnosis of DVT relies on imaging technologies, such as ultrasound and computed tomography (CT) venography[9]. This study was conducted to compare the impacts of 70 kV and 100 kV combined with ASIR-V technique in CT venography of lower limb DVT

Methods

Results

Conclusion