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Abstract
BackgroundSolitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest. A subset of SFTP follows a malignant course, sometimes several years after complete resection. Traditional scoring systems based on clinical and histological features are poor predictors of biological behavior. This study aimed to investigate tumor-associated miRNAs expression as novel biomarkers to predict the clinical behavior of SFTP.MethodsFormalin-fixed and paraffin-embedded SFTP tissues blocks from patients surgically resected between 1992 and 2013 at two tertiary care teaching hospitals were included. SFTP tumors were categorized as either malignant or benign variants according to the WHO classification. Following miRNAs levels were measured: let-7a, miR-16b, miR-17, miR-21, miR-31, miR-34a, miR-92a, miR-125a, miR-125b, miR-195-5b, miR-203a, and miR-223. Differential gene expressions which were calculated with the threshold cycle (Ct) method were compared among the two variants.ResultsThirty-eight patients (40% male, mean age 62.2 (±10.9) years) were included. Expression levels of miR-125b showed a significant difference between benign compared to malignant variants (−3.08 ± 0.93 vs. -2.22 ± 1.36, p = 0.0068). Furthermore, lower levels of miR-125b were found to be associated with increased tumor size (p = 0.0414). Thus, downregulation of miR-125b indicates malignant transformation. All other investigated miRNAs were not associated with grading of SFTP.ConclusionsOur data suggest a potential role of miR-125b in the pathogenesis of tumor growth and malignant transformation of SFTP, respectively. Further studies have to address the potential use of miRNA-125b as a biomarker or therapeutic target in SFTP.
Highlights
Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest
Since there is growing evidence that miRNAs might be of major interest in the diagnosis and prognosis of different diseases including lung cancer [18] and mesothelioma [19], this study aimed to investigate the role of miRNAs as biomarkers to predict the clinical behavior of SFTP
When tumor size was compared to miR-125b levels, we found that expression levels of miR-125b inversely correlated with tumor size (Fig. 4b), indicating that lower levels are associated with an increase in tumor size (p = 0.0414)
Summary
Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest. Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia within the chest cavity with an estimated incidence of approximately 0.2/100’000 persons per year [1], and account for 5% of all pleural tumors [2]. England et al were the first to describe six clinicopathologic features predicting a malignant behavior. These risk factors included tumor size, localization, sessile tumor, existence of necrosis or hemorrhage, high mitoses count, and evidence of nuclear pleomorphism [9]. Several multivariable models identified these characteristics which are based exclusively on clinico-pathologic features as poor predictors for the biological behavior of SFTP [15,16,17]. There is insufficient data on immune-histochemical and molecular markers predicting the outcome of SFTP
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