Low-Temperature Synthesis and Antibacterial Activity of Hybrid Systems of Gentamicin Sulfate with Copper and Iron Nanoparticles

Abstract

Cryochemical modification methods are used to obtain hybrid composites of the antibacterial drug gentamicin sulfate, as well as copper and iron nanoparticles, which are promising precursors of the targeted drug delivery systems. The resulting systems are antibiotic nanoparticles of 50 to 300 nm, including copper and iron nanoparticles of 1 to 20 nm (according to the results of physicochemical analysis by IR spectroscopy, X-ray diffraction analysis, dynamic light scattering, and scanning and transmission microscopy). The composites obtained showed higher antibacterial activity against E. coli, P. aeruginosa, and B. cereus compared to the individual components.