Abstract
This study is designed to investigate the effect of low temperature plasma (LTP) on the apoptosis of CNE‐2Z cell (human nasopharyngeal carcinoma cell line) and the potential mechanisms. We find out that LTP provoked the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in CNE‐2Z cells and significantly inhibit the cell viability and induce cell apoptosis. Furthermore, the antioxidant N‐acetyl cysteine (NAC) almost completely blocked LTP‐induced apoptosis. LTP triggered mitochondrial and endoplasmic reticulum (ER) stress‐induced apoptotic pathways indicated by significant upregulation of CHOP, p53, and Bax‐to‐Bcl‐2 ratio. This work will provide the molecular theoretical basis of clinical application of LTP for the treatment of human nasopharyngeal carcinoma.
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