Low T3 syndrome is a predominant thyroid dysfunction among coronary heart disease patients: an Egyptian angiographic study

Abstract

Background Cardiovascular diseases are the most common cause of mortality, primarily affecting older adults. Although the established risk factors explain most cardiac risks, alternative biochemical markers may have an assisting diagnostic role in identifying those at risk for a clinical cardiovascular event, among the abnormal thyroid gland profiles. Aim We aimed to investigate the cardiovascular risk of thyroid profile abnormalities among patients with clinical coronary heart disease (CHD) confirmed by coronary angiography (CA). Patients and methods An observational, prospective case–control study. Ninety cases participated in the study. They were divided into two groups: Group I (n=60) CHD patients were diagnosed by percutaneous (CA) and group II (30 participants) with negative diagnostic workup for CHD who were enrolled as the control group or (non-CHD group). Thyroid hormones profiles were withdrawn from both groups. Results Group I (CHD patients proved by CA) had statistically significant higher age (55.18±12.303 vs. 48.73±13.014 years, P=0.024), blood glucose (207.55±74.186 mg%; P=0.002), blood urea (37.65±12.658 vs. 28.97±9.152 mg%, P=0.001), and cholesterol (246.67+99.348 vs. 199.67±47.593 mg%, P=0.003). T3 levels are significantly lower in group I (2.094±0.971 vs. 2.73+0.7221 pg/ml, P=0.002). Conclusion Our results concluded that low T3 syndrome is the predominant thyroid dysfunction in CHD patients who underwent a CA.