Abstract
ObjectiveThe association ns between prediabetes and androgens have been rarely reported, especially in Chinese men. We aimed to investigate whether androgens were associated with the prevalence of prediabetes diagnosed with new American Diabetes Association criteria in Chinese men and then to assess which androgen value was the most relevant factor.MethodsA total of 2654 men (52.6±13.4 years old) were selected. Serum total testosterone (TT), sex hormone-binding globulin (SHBG) and free testosterone (FT) were measured. Covariance analysis of different androgen values were performed in age subgroups. Multinomial logistic regression was used for the association of TT, SHBG and FT with prediabetes and diabetes, as well as prediabetes in age subgroups.ResultsAccording to ADA new criteria, normoglycemia, prediabetes, and diabetes were diagnosed in 1405, 907 and 342 men, respectively. In covariance analysis, SHBG of prediabetes were found lower than that of normoglycemia but higher than that of diabetes (P <0.05). In multinomial logistic regression, serum TT and SHBG were inversely associated with prediabetes and diabetes. While, after full adjustment for age, residence area, economic status, waist circumference, metabolic factors, other two androgen values and HOMA-IR, only the associations of SHBG with prevalence of prediabetes and diabetes persisted statistically significant, especially in the elderly with prediabetes (all P for trend <0.05).ConclusionsSerum androgen was inversely associated with prediabetes and diabetes in Chinese men. Low serum SHBG was the most relevant factor for prediabetes and diabetes. Whether it is an independent predictor for incident prediabetes in Chinese men needs further explorations.
Highlights
Type 2 diabetes mellitus (T2DM), the major component of diabetes mellitus, is a highly prevalent complex chronic disease in China, where the age-standardized prevalence has rapidly increased from 9.7% in 2008 to 11.6% in 2010 [1]
We aimed to investigate whether androgens were associated with the prevalence of prediabetes diagnosed with new American Diabetes Association criteria in Chinese men and to assess which androgen value was the most relevant factor
Serum TT and sex hormone-binding globulin (SHBG) were inversely associated with prediabetes and diabetes
Summary
Type 2 diabetes mellitus (T2DM), the major component of diabetes mellitus, is a highly prevalent complex chronic disease in China, where the age-standardized prevalence has rapidly increased from 9.7% in 2008 to 11.6% in 2010 [1]. The phenomena that both serum testosterone levels of young Chinese men and the rates of hormone related cancers in older Chinese men are significantly lower than those of Western populations [4], suggesting that low testosterone may be one of the potential risk factors contributing to the prevalence of T2DM in China other than overweight and obesity. It has been reported that approximately 25% to 40% of diabetic men have low testosterone levels [5, 6], as well as male patients with hypogonadism, such as Klinefelter’s syndrome, have an increased incidence of diabetes [7]. The associations between serum TT, FT and SHBG and T2DM in male populations were not identical in previous investigations [6, 8,9,10,11,12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
