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Abstract
The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen. Cathelicidin levels were significantly lower in both treated ( n = 15) and untreated leprosy patients ( n = 14) when compared to controls ( P < 0.001). Within leprosy patients, levels were lower in those who very recently developed disease (untreated group) when compared to already treated patients ( P < 0.05). 25OH-vitamin D3 levels were not different between groups. The results suggest a potential association of cathelicidin LL-37 with Mycobacterium leprae infection.
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