Low salt intake during pregnancy and lactation causes growth delay and modifies lipid profile in adult female Wistar rat offspring.

Abstract

ObjectiveTo evaluate body size and lipid profile in adult female offspring (off) in Wistar rats whose dams were fed low salt diet during pregnancy and lactation.MethodsFemale Wistar rats were fed low (LSD: 0.15%) or normal (NSD 1.3% NaCl) salt diet from 8 to 18 weeks of age. At 12 weeks of age, they were mated. Body weight (BW) was measured on the day of birth and since weaning all off groups were fed NSD. With 40 days of age, off from LSD and NSD groups were ovariectomized (OVX) or not (SHAM). At 12 weeks of age, OVX or SHAM rats were housed in 4oC or at room temperature (RT) during 24 hours and triacilglicerols (TG), cholesterol (CHO), naso‐anal length (NA) were measured.Results(mean±SEM, p<0.05, n= 5/group: BW (g) was lower at the birth in LSDoff (5.1±0.2) than in NSDoff (5.9 ±0.1). In SHAM, the NA (cm) was lower in LSDoff (20.3±0.1) than in.NSDoff (21.1±0.2). In OVX, NA in LSDoff (22±0.5) and NSDoff (22±0.2) were higher compared to the SHAM. TG (mg/dL) was lower at 4oC than at RT in LSDoff SHAM (25±3 vs. 96±23), however in NSDoff SHAM low temperature did not alter TG. In OVX groups, TG was lower in 4°C, both in NSDoff (RT = 122±19, 4°C = 45±7) and LSDoff (RT = 72±14, 4±C = 41±6). CHO decreased in response to 4ºC only in SHAM and OVX NSDoff.ConclusionsLow salt diet during pregnancy and lactation causes growth delay and lipid alterations in response to low temperature. These effects are modified by OVX.Supported by FAPESP