Abstract
To the Editor: Local recurrence rates of high-risk cutaneous squamous cell carcinoma (SCC) are lower after Mohs micrographic surgery compared with conventional excision.1 Although local recurrence rates of primary cutaneous SCC after Mohs micrographic surgery are low,1,2 local recurrence can reach 15% or higher for tumors with high-risk factors.3 Adjuvant AE1/AE3 cytokeratin immunohistochemical stains ease visualization of SCC in challenging cases by helping to identify single-cell spread, neoplastic cells masked by inflammation, and perineural invasion.
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