Abstract
Low reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty years, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term LLLT has become widely recognized in the field of regenerative medicine. In this review, we will describe the mechanisms of action of LLLT at a cellular level and introduce the application to mesenchymal stem cells and mesenchymal stromal cells (MSCs) therapies. Finally, our recent research results that LLLT enhanced the MSCs differentiation to osteoblast will also be described.
Highlights
Mesenchymal stromal cells (MSCs) are the promising source for the regenerative medicine and repair of various tissues in the treatment of a range of diseases
We have reported that the laser irradiation to MSCs influences cell differentiation and possible mechanisms of cells differentiation by laser were proposed [2,3,4]
Fu et al showed that circadian rhythms mediate bone formation [124], and Kawasaki et al reported that the E-box motif, a circadian regulatory sequence, is involved in the osteoblast expression of bone morphogenetic protein(BMP-) 4 [125]; these findings indicate that CRY proteins regulate various homeostatic and physiological events via Ebox elements
Summary
Mesenchymal stromal cells (MSCs) are the promising source for the regenerative medicine and repair of various tissues in the treatment of a range of diseases. We will summarize typical results of the LLLT application to MSCs therapies
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