Abstract
Objectives:To test the image quality and feasibility of a sequential low radiation dose protocol for hybrid cardiac PET/CT angiography (CTA).Background:Multidetector computed tomography (MDCT) is a non-invasive method for coronary angiography. The negative predictive value of MDCT is high but perfusion imaging has a role in detecting functional significance of coronary lesions. This has encouraged combining these techniques. However, radiation dose is of concern. We report our first experiences with a low dose sequential CTA mode applicable to hybrid imaging.Methods:In the first phase, 10 consecutive cardiac MDCT angiographies were performed with spiral acquisition and compared in terms of image quality and dose with the following 10 patients performed with a new sequential mode. In the second phase, feasibility and radiation dose of a combined 15O-water rest-stress PET perfusion/sequential CTA protocol were assessed in another group of 61 consecutive patients.Results:Mean effective radiation dose was 60% lower in the sequential group than in the spiral group (19·3 versus 7·6 mSv, P<0·001). In the second phase, the new sequential hybrid protocol proved possible in 87% of the patients given the preconditions determined by the manufacturer. Mean effective dose of the CT acquisition was 7·6 mSv and total dose from the PET/CTA hybrid study 9·5 mSv.Conclusion:Low dose PET/CT allows cardiac hybrid studies with <10 mSv. The protocol can be applied to almost nine out of 10 patients with CT image quality comparable to spiral acquisition.
Highlights
On the presence, severity, and characteristics of CAD including. These findings suggest that CT angiography and myocardial the visualization of luminal obstruction and atherosclerotic perfusion imaging are complementary rather than substitutive plaque, constitutes an attractive addition to previously available methods to evaluate CAD (Schuijf & Bax, 2008). and that is why diagnostic tools (Berman et al, 2006; Einstein et al, 2007)
In the first part of the study, a standard spiral and a sequential, prospectively triggered Multidetector computed tomography (MDCT) protocol were compared by means of image quality and radiation dose
After an initial acquisition to calculate calcium score, ten consecutive MDCT angiography studies were performed with spiral acquisition while the following ten patients were imaged using step-and-shoot mode if and when the inclusion criteria after possible premedication were met
Summary
Accepted for publication Received 19 June 2008; accepted 30 September 2008 protocol for hybrid cardiac PET⁄CT angiography (CTA). Background: Multidetector computed tomography (MDCT) is a non-invasive method for coronary angiography. The negative predictive value of MDCT is high but perfusion imaging has a role in detecting functional significance of coronary lesions. We report our first experiences with a low dose sequential CTA mode applicable to hybrid imaging
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
