Abstract
Background and Aims : Atherosclerotic cardiovascular disease (CVD) has been associated with non-alcoholic fatty liver disease (NAFLD). Bile acids (BAs) play important roles in cholesterol and lipid metabolism, coordinating major CVD risk factors. We generated Cyp2c70-/- mice with a human-like BA composition lacking mouse-specific muricholic acids (MCAs) to accelerate translation from mice to humans. We employed this model to investigate the links between BAs and CVD risk factors.
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