Abstract
Active cytomegalovirus infection is not uncommon in critically ill non-immunosuppressed patients. We conducted a preliminary observational study to determine the prevalence of active cytomegalovirus infection in cardiovascular surgical patients. One hundred patients admitted to the intensive care unit following cardiovascular surgery were enrolled between January 2010 and May 2010. Four patients (4%) were positive for serum pp65 antigens, though cytomegalovirus-positive serology (immunoglobulin G, IgG) was found in 98 patients (98%) including those four patients. Active cardiac diseases and their operative procedures including cardiopulmonary bypass may not be significant risk factors for active cytomegalovirus infection unless systemic derangements are also present.
Highlights
Active cytomegalovirus infection is not uncommon in critically ill non-immunosuppressed patients
We conducted a preliminary observational study to determine the prevalence of active CMV infection in cardiovascular surgical patients
Characteristics of antigenpositive patients included: patient 1 had a history of rheumatic arthritis on long-term corticosteroids, who underwent elective aortic valve replacement with perioperative steroid supplementation; patient 2 had a diagnosis of native-valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA), which required emergency aortic valve replacement; patient 3 underwent Y graft replacement, complicated with postoperative acute kidney injury (AKI) due to left gluteal muscle ischemia and rhabdomyolysis; Patient 4 had a history of receiving adjuvant chemotherapy with orally active fluoropyrimidine against residual gastric cancer, who underwent off-pump coronary artery bypass grafting before radical gastrectomy
Summary
Active cytomegalovirus infection is not uncommon in critically ill non-immunosuppressed patients. We conducted a preliminary observational study to determine the prevalence of active cytomegalovirus infection in cardiovascular surgical patients. One hundred patients admitted to the intensive care unit following cardiovascular surgery were enrolled between January 2010 and May 2010. Four patients (4%) were positive for serum pp antigens, though cytomegalovirus-positive serology (immunoglobulin G, IgG) was found in 98 patients (98%) including those four patients. Active cardiac diseases and their operative procedures including cardiopulmonary bypass may not be significant risk factors for active cytomegalovirus infection unless systemic derangements are present
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