Abstract
Factors underlying vulnerability to alcoholism are largely unknown. We identified an innate endophenotype in rodents that predicted individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related cell-adhesion molecule PSA-NCAM. Depletion of PSA-NCAM within the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data demonstrate a novel mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
