Abstract
Plasma testosterone, estradiol, estrone and luteinizing hormone concentrations were measured by radioimmunoassay in healthy volunteers who after fasting for 10 h consumed 1.5 g ethanol/kg body wt. Of this group five suffered from severe hangover while another five had essentially no hangover. Ten to twenty hours after drinking, the testosterone concentrations were significantly decreased in all subjects, but in the 5 subjects with severe hangover the decrease was more pronounced. Estradiol values decreased during the hangover period, but were normal at the time of acute intoxication, whereas estrone values, in the few cases determined, showed a tendency to increase during acute intoxication. A compensatory increase in the plasma concentration of luteinizing hormone was found in all subjects.
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