Low Plasma Cholecalciferol as Independent Risk Factor for Covid19 Infection

Walaa Fikry Elbossaty

doi:10.26717/bjstr.2021.33.005419

Abstract

Walaa Fikry Elbossaty* Author Affiliations Department of Biochemistry, Faculty of Science, Damietta University, Egypt Received: January 12, 2021 | Published: February 01, 2021 Corresponding author: Walaa Fikry Elbossaty, Department of Biochemistry, Faculty of Science, Damietta University, Egypt DOI: 10.26717/BJSTR.2021.33.005419

Highlights

The imbalance in the immune system is one of the most important causes of infection with Covid 19, so fixing that defect is one of the most important ways to eliminate Covid 19, so scientists sought to search for substances that contribute to raising the efficiency of the immune system and repairing the defect
The indicators showed that patients who had Covid-19 were classified into two groups according to the measurement of the rate of vitamin D3 in their sera, and it was found that the patients who had an adequate level of vitamin had mild symptoms and their disease did not deteriorate and the chance of recovery was much more compared to the group characterized by a lack of vitamin D In their serum, in contrast, the death rate increased in people with low vitamin D3 levels compared to those with abundant vitamin D3 levels [3]
Since 1930, vitamin D3 supplements have been used in treating respiratory diseases and fighting viruses, and the main reason for using it may be that vitamin D3 plays an important role as an antiviral, by stimulating natural immunity and the currency of autophagy that contributes to the elimination of the virus [4]

Summary

Introduction

The imbalance in the immune system is one of the most important causes of infection with Covid 19, so fixing that defect is one of the most important ways to eliminate Covid 19, so scientists sought to search for substances that contribute to raising the efficiency of the immune system and repairing the defect. Since cholecalciferol (vitamin D3) has effective importance on the immune system, in addition to being an antibacterial and virus, it is here a distinct factor in controlling Covid 19 This is what has been confirmed in scientific research that has confirmed that increasing the concentration of vitamin D contributes to raising the efficiency of the immune system and overcoming and controlling the risk of the virus, reducing mortality rates and raising the level of recovery. One of the most important mechanisms to eliminate Covid 19 by using vitamin D3 supplements is that vitamin D3 affects the renin-angiotensin system (RAS) and it has been found that the high rate (RAS) contributes to the development of Covid 19 This indicates that vitamin D3 affects Virus development in an indirect way through its influence on RAS [5]. Vitamin D3 was defined as an antimicrobial from 30 years ago, and the mechanisms of action of the vitamin may be multiple as it has the ability to produce nitric oxide and superoxide, and it increases the efficiency of monocyte / macrophage antimicrobial functions through its effect on increasing toll-like secretion, receptor 2, NOD2, and cathelicidin from immune cells, Vitamin D3 has anti-viral properties through its effect on immune cells and encouraging the autophagy process (Figure 1) [12]

Discussion

Conclusion