Abstract
The aim of this study was to assess if levels of markers of nitric oxide (NO) formation and oxidative stress are associated to responses to sildenafil in patients with erectile dysfunction (ED). We studied 28 health controls, 26 patients with ED (ED group), and 18 patients with ED and diabetes mellitus (ED/DM group). The five‐item version of International Index for Erectile Function (5‐IIEF) questionnaire was used to assess the erectile function, and sildenafil responsiveness was assessed as the change of 5‐IIEF score (after sildenafil minus before sildenafil). Levels of whole blood nitrite, antioxidants markers (ferric reducing ability of plasma; FRAP and glutathione; GSH), oxidative stress markers (thiobarbituric acid reactive substance; TBARS and carbonyl) were determined. While we found a negative correlation between whole blood nitrite level and the responses to sildenafil in both ED groups, FRAP correlated negatively with the responses to sildenafil only in the ED/DM group. No other significant differences were found. Our finding show evidence that low NO bioavailability predicts better responses to sildenafil in patients with ED, with or without DM. Supported by CNPq and FAPESP
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