Abstract
Few studies have addressed the mother-to-child transmission of Th2 immunity and the impact on the development of atopic diseases in early childhood. We investigated 186 children who were followed-up regularly for 4 years in a birth cohort study. The levels of Th2 related chemokine (C-C motif) ligand 17 (CCL17) and CCL22 were quantified in cord blood and at 1.5 years-of-age using multiplex Luminex kits. The levels of 125 pairs of CCL17 and CCL22 chemokines from birth to 1.5 years were recorded in this study. Using K-means clustering, only the declining trend of CCL22 levels was separately clustered (cluster A, n = 51; cluster B, n = 46; cluster C, n = 28). Mothers of children with higher CCL22 chemokine levels at birth were significantly more likely to display Dermatophagoides pteronyssinus sensitization. A lower CCL22 level at birth with a slight rise during infancy was associated with higher prevalence of mite sensitization and a higher risk of asthma at 3 years-of-age (P = 0.014). In conclusion, low mother-to-child Th2-associated chemokine CCL22 levels appear to be inversely related to mite sensitization and the risk of asthma development in early childhood.
Highlights
ObjectivesThe aim of this study was to determine the levels of Th2-associated chemokines CCL17 and CCL22 at birth and 1.5 years-of-age in children from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study
Atopic diseases are characterized by a T helper (Th) 2-skewed immunity
This study has demonstrated that children with Th2-skewed immunity at birth are significantly more likely to have been born to mothers with mite sensitization but are not associated with the risk of atopic disease development later in life
Summary
The aim of this study was to determine the levels of Th2-associated chemokines CCL17 and CCL22 at birth and 1.5 years-of-age in children from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study
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