Abstract
Low molecular weight heparins (LMWHs) are the standard agents used for antithrombotic therapy and prophylaxis. Despite their widespread use, reports about adverse effects from LMWHs are very scarce. Heparin-induced skin necrosis at the injection site is a rare adverse effect, more commonly associated with unfractionated heparin (UFH) rather than with LMWH, while its mechanism remains unclear. This paper deals with the enoxaparin induced skin necrosis.
Highlights
Heparin preparations are important anticoagulants and have been successfully used for the prevention and treatment of thromboembolic disorders for many years in most surgical units
We report the rare occurrence of skin necrosis that developed after enoxaparin administration
After a Medline literature search, we have found 25 cases of skin necrosis associated with Low molecular weight heparins (LMWHs) until May 2009
Summary
Heparin preparations are important anticoagulants and have been successfully used for the prevention and treatment of thromboembolic disorders for many years in most surgical units. After a Medline literature search, we have found 25 cases of skin necrosis associated with LMWH until May 2009
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