Low MGAT3 expression identifies long-term survivors with high grade serous ovarian cancer

Abstract

Introduction: MGAT3 gene expression is implicated in oncogenic signaling pathways. We recently found that MGAT3 expression correlated with the presence of bisecting GlcNAc on N-glycoproteins in ovarian cancer cells. MGAT3 encodes the enzyme attaching bisecting GlcNAc to these glycoproteins. We investigated (i) how MGAT3 expression is regulated, (ii) whether DNA methylation, MGAT3 expression, and bisecting GlcNAc presence are functionally linked, and (iii) whether MGAT3 expression has any predictive value.