Abstract
BackgroundExisting data about the prognostic value of absolute count of blood cells in gastric cancer was limited. Thus, the present study aims to investigate the prognostic value of absolute count of white blood cell (WBC), neutrophil, lymphocyte, monocyte and platelet in gastric cancer patients.MethodsFrom September 2008 to March 2015, 3243 patients treated with radical gastrectomy were enrolled in the present study. Clinicopathological characteristics were recorded. The prognostic value of blood test in gastric cancer patients were analyzed.ResultsThere were 2538 male and 705 female. The median age was 58 years (range 20–90). The median follow-up time was 24.9 months (range 1–75). The 1-, 3- and 5-year overall survival rate was 88.9%, 65.8% and 57.2%, respectively. The optimal cut off value was 6.19 × 109/L for WBC (P = 0.146), 4.19 × 109/L for neutrophil (P = 0.004), 1.72 × 109/L for lymphocyte (P = 0.000), 0.51 × 109/L for monocyte (P = 0.019) and 260.0 × 109/L for platelet (P = 0.002), respectively. Neutrophil, lymphocyte, monocyte and platelet were risk factors for the prognosis of gastric cancer (all P < 0.05). However, only lymphocyte and monocyte were independent risk factors (both P < 0.05). Combination of lymphocyte and monocyte could increase the prognostic value for gastric cancer patients, especially in stage II/III gastric cancer patients.ConclusionsHigh absolute count of neutrophil, monocyte and platelet, and low absolute count of lymphocyte were associated with poor prognosis of gastric cancer. However, only lymphocyte and monocyte count were independent prognostic predictors. Combination of lymphocyte and monocyte count could further increase the predictive value for gastric cancer.
Highlights
Existing data about the prognostic value of absolute count of blood cells in gastric cancer was limited
The results showed that combination of lymphocyte and monocyte count could increase the predictive value for the prognosis of the entire cohort
The results showed that both lymphocyte and monocyte could predict the prognosis of stage II/III gastric cancer patients (Fig. 3)
Summary
Existing data about the prognostic value of absolute count of blood cells in gastric cancer was limited. The present study aims to investigate the prognostic value of absolute count of white blood cell (WBC), neutrophil, lymphocyte, monocyte and platelet in gastric cancer patients. The prognosis and treatment of gastric cancer patients after radical gastrectomy mainly depends on TNM stage system. The prognosis of gastric cancer patients could be various even with the same tumor stage. Prognostic value of blood test parameters in gastric cancer patients has been investigated by numerous studies [1, 2]. The prognostic value of absolute count of blood cells, which was more convenient, has rarely been investigated in gastric cancer patients
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