Abstract
The Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model develops and progresses through all stages of carcinogenesis. We, (Zuniga et al., Cancer Prev. Res. 2013) previously demonstrated a high lycopene tomato powder (TP) was effective in reducing carcinogenesis in the TRAMP model. The objective of the current study was to determine if a low-lycopene TP (20 fold less than previously tested) impacted carcinogenesis and androgen biology at 3 time points. 8-week-old male C57BL/6 X FVB TRAMP mice were randomized to consume either an AIN-93G + 10% TP diet (N=90) or the AIN-93G control diet (N=88) and assigned to one of three sacrifice ages: 12 (N=59), 16 (N=60), or 20 (N=59) weeks. There was no difference between diets in overall cancer incidence at each time point. TP significantly increased serum testosterone (p=0.01) and expression of prostatic androgen receptor in high-grade PIN lesions (p=0.01) at 20 weeks of age compared to the control, suggesting an interaction between tomato components and androgen status in pre-neoplastic prostate tissue. The results suggest that lycopene content of TP is a crucial modulator of PCa in TRAMP mice. We have shown that a low-lycopene TP is ineffective in reducing carcinogenesis in the TRAMP model. Support was provided by USDA Hatch grant #ILLU-971-348 and UIUC Margin of Excellence Research award.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
