Low-level Progesterone on the Day of hCG Injection Has No Detrimental Effect on the Pregnancy Outcome after IVF with GnRH-a Protocol: A Retrospective Study

Jie Hao ,Bin Xu ,Yonggang Wang ,Yanping Li ,Jing Zhao

doi:10.33696/gynaecology.1.004

Abstract

To investigate the effect of low progesterone (P) level on the day of human chorionic gonadotropin (hCG) injection on the outcome of in vitro fertilization (IVF) with GnRH- agonist (GnRH-a) long protocol

Highlights

Progesterone (P) can be synthesized and secreted by the ovary and the adrenal glands
Low P level on the day of human chorionic gonadotropin (hCG) injection may have a trend towards higher implantation and clinical pregnancy rates after in vitro fertilization (IVF) cycles with GnRH- agonist (GnRH-a) long protocol
The analysis indicated that duration of infertility, P level were negatively correlated with clinical pregnancy, and that increased length of stimulation, endometrial thickness and the number of high quality embryo were associated with improved clinical pregnancy rates (Table 5)

Summary

Introduction

Progesterone (P) can be synthesized and secreted by the ovary and the adrenal glands. Granulosa cells and theca cells produce P. In the later stage of follicular, P is produced by mature granulosa cells before the luteinizing hormone (LH) peak [1], and plays a key role in the regulation ovulation [2]. During the process of controlled ovarian stimulation (COS), the premature LH surge could be avoidable with GnRH- agonist (GnRH-a) / GnRH-ant [3]. The elevation of P level would be avoided in most COS cycles because of the reduced LH level. P elevation during late follicular phase still occurs in about 38% of all in vitro fertilization cycles [4,5]

Methods

Results

Conclusion