Low level of serum sex hormone binding globulin is associated with the occurrence of metabolic syndrome

Abstract

Objective To investigate the relationship between serum sex hormone binding globulin (SHBG)and metabolic syndrome (MS) in Chinese young population.Methods A total of 797 patients were enrolled and subdivided into MS group(n=377)and non-MS group(n =420).Body height and weight were measured for body mass index(BMI),and waist and hip circumstances for waist-to-hip ratio (WHR).Glutamate aminotransferase,aspartate aminotransferase,serum lipid level,fasting glucose and fasting insulin were determined.The level of serum SHBG was measured by chemiluminescent microparticle immunoassay.HOMA-IR was employed to evaluate the insulin sensitivity.Results The serum SHBG level of non-MS group was significantly higher than that in MS group[(34.97± 33.97 vs 19.54 ± 15.54) nmol/L,P＜0.001].After adjusted for age,sex,BMI,and WHR,serum SHBG level was negatively associated with diastolic blood pressure,fasting plasma glucose,fasting insulin,homeostasis model assessment for insulin resistance (HOMA-IR),and triglycerides (P ＜ 0.05),but it was significantly positively associated with HDL-C (P ＜ 0.001).After adjusted for age,sex,BMI,WHR,and HOMA-IR,binary logistic regression analysis showed that serum SHBG level was negatively associated with metabolic syndrome.Conclusions In Chinese young population,low level of serum SHBG is associated with the occurrence of metabolic syndrome. Key words: Chinese young population ; Sex hormone binding globulin ; Metabolic syndrome