Abstract
BACKGROUND: It is unclear about the association between vitamin D level and target organ damage in elderly patients with type 2 diabetes in China. Aim of this study was to investigate the relationship between vitamin D level and target organ damage in elderly patients with type 2 diabetes of Chinese population. 
 
 METHODS: A retrospective study was performed on 254 elderly patients with type 2 diabetes (148 males and 106 females). According to assay of 25-hydroxy vitamin D [25(OH)D], the participants were divided into a deficiency group (n=129), an insufficiency group (n=77) and a sufficiency group (n=48). The clinical indicators of target organ damages among these groups were analyzed, and multivariate logistic regression analysis was performed to predict the target organ damage. 
 
 RESULTS: Approximately 81.1% of patients were the low level of 25(OH)D with mean 25(OH)D below 30ng/ml. When compared with those in the sufficiency group, the level of left ventricular absolute mass index (LVMI), the morning urine albumin/uric creatinine ratio (ACR) and carotid intimal medial thickness (cIMT) increased significantly and creatinine clearance rate (CcR) decreased significantly in the deficiency group (P<0.05). The level of ACR and cIMT in the insufficiency group also increased significantly (P<0.05). There was a higher proportion in kidney, brain, artery and total target organ damage in the deficiency group or insufficiency group than those in the sufficiency group (P<0.05). Logistic regression analysis showed that low-level 25(OH)D  (< 30ng/ml) was independently associated with total target organ damage in patients with elderly type 2 diabetes (OR = 3.58; 95%CI: 1.60-8.02,P =0.002)
 
 CONCLUSIONS: A condition of hypovitaminosis D is commonly present in Chinese patients with elderly type 2 diabetes. The low level of 25(OH)D may contribute to aggravate target organ damage of elderly type 2 diabetes.
Highlights
Type 2 diabetes can shorten a patient's life expectancy by 10 years (Shlomo et al, 2005)
There was a higher proportion in kidney, brain, artery and total target organ damage in the deficiency group or insufficiency group than those in the sufficiency group (P
Logistic regression analysis showed that low-level 25(OH)D (< 30ng/ml) was independently associated with total target organ damage in patients with elderly type 2 diabetes (OR = 3.58; 95%CI: 1.60-8.02,P =0.002)
Summary
Type 2 diabetes can shorten a patient's life expectancy by 10 years (Shlomo et al, 2005). The overall prevalence of diabetes was estimated to be 11.6% in the Chinese adult population by the 2010 China noncommunicable disease surveillance group (Xu et al, 2013). The leading causes of death and disability of type 2 diabetes are chronic target organ damage, including heart, brain and kidney damage. 75–80% patients with diabetes died from macroangiopathy, especially from cardiovascular disease. It is unclear about the association between vitamin D level and target organ damage in elderly patients with type 2 diabetes in China. Aim of this study was to investigate the relationship between vitamin D level and target organ damage in elderly patients with type 2 diabetes of Chinese population
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