Abstract
PurposeTo determine the incidence of new choroidal neovascularization (CNV) in eyes with dry age-related macular degeneration (AMD) following subthreshold diode micropulse laser (SDM).MethodIn an observational retrospective cohort study, the records of all patients active in the electronic medical records database were reviewed to identify eyes with dry AMD treated with SDM. Identified eyes were classified by simplified AREDS categories, and analyzed for the primary endpoint of new CNV after treatment.ResultsThe EMR revealed SDM was offered to 373/392 (95%) patients with dry AMD and elected by 363/373 (97%) between 2008–2017. Follow up was available for 354/363 patients (547 eyes, 98%) (range 6–108 mos., avg. 22). CNV risk factors included age (median 84 years, 67% > 80); reticular pseudodrusen (214 eyes, 39%); AREDS category (78% category 3 and 4); and fellow eye CNV (128 eyes, 23%). New CNV developed in 9/547 eyes (1.6%, annualized rate 0.87%). Visual acuity was unchanged. There were no adverse treatment effects.SummaryIn a review of a large group of eyes with exceptionally high-risk AMD, SDM was followed by a very low incidence of new CNV. If confirmed by further study, SDM would offer a new and highly effective treatment to reduce the risk of vision loss from AMD.
Highlights
To determine the incidence of new choroidal neovascularization (CNV) in eyes with dry agerelated macular degeneration (AMD) following subthreshold diode micropulse laser (SDM)
[41] In this report we examine the incidence of choroidal neovascularization (CNV) in eyes with dry AMD following SDM
392 patients (590 eyes) with dry AMD of Age-Related Eye Disease Study (AREDS) category 2 or greater in at least one eye were identified in the EMR, containing records of all patient visits between April of 2014 through May of 2017. 373 (95%) were offered SDM. 19 patients (27 eyes, 5%) were not offered treatment due to non-ophthalmic considerations. 10 patients (16 eyes, 3%) declined treatment
Summary
In an observational retrospective cohort study, the records of all patients active in the electronic medical records database were reviewed to identify eyes with dry AMD treated with SDM. Identified eyes were classified by simplified AREDS categories, and analyzed for the primary endpoint of new CNV after treatment
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