Low-grade pelvic masses with spindle cell and fibroblastic proliferation: a case report

John Micha,Douglas Ellison,Bram Goldstein,John Brown,Mark Rettenmaier

doi:10.1186/1752-1947-1-16

Abstract

BackgroundAbdominal-pelvic masses containing spindle cell and fibroblastic proliferation are very rare. Since scant studies have reported on the pathologic characteristics inherent in this disease, appropriate clinical management is undetermined.Case presentationWe report on an 87 year-old woman who presented with large abdominal pelvic masses, ascites, ureteral obstruction, and an elevated CA-125 serum level. The patient underwent surgical resection of the lesions and has since done very well. Final pathology revealed a low-grade ovarian tumor with spindle cell and fibroblastic proliferation.ConclusionTo the best of our knowledge, this appears to be the only reported clinical case of a patient with this rare histology.

Highlights

Abdominal-pelvic masses containing spindle cell and fibroblastic proliferation are very rare
Low-grade pelvic masses with spindle cells and fibroblastic proliferation are very rare, poorly recognized, and not well described in the literature [1]. This histologic subtype has been associated with anaplastic thyroid carcinoma, medullary thyroid carcinoma, and can reportedly manifest itself as a low-grade fibrosarcoma, malignant fibrous histiocytoma, myxofibrosarcoma, and fibrosingtype fibrosarcoma [2,3]
We describe the first reported case involving the diagnosis and clinical management of a patient with low-grade abdominal pelvic masses exhibiting spindle cell and fibroblastic proliferation

Summary

Introduction

Abdominal-pelvic masses containing spindle cell and fibroblastic proliferation are very rare. Conclusion: To the best of our knowledge, this appears to be the only reported clinical case of a patient with this rare histology. Low-grade pelvic masses with spindle cells and fibroblastic proliferation are very rare, poorly recognized, and not well described in the literature [1]. Myxofibrosarcomas and fibromyxoid sarcomas containing spindle cell and fibroblastic proliferation are not well recognized or classified, and primarily are reported in pathology journals [1,3,4].

Results

Conclusion