Abstract
BackgroundThe term low-grade oncocytic tumour of kidney is an emerging entity describing CD117-negative and cytokeratin 7-positive indolent tumors with overlapping morphological features between oncocytic tumors.Case presentationWe present herein the case of a 77-year-old female with a 3.2-cm nodule in mid pole of the left kidney. The tumor was uniformly oncocytic with solid, compact nested and trabecular growth patterns. There was common areas of transition to central zones of stromal edema with marked tumor hypocellularity and growth in cords. Some of these areas had adjacent fresh hemorrhage. Immunohistochemistry showed strong and diffuse expression of cytokeratin 7 and negativity for cKIT/CD117.ConclusionThe proper use of this new diagnostic category avoids labeling such tumors as unclassified renal cell carcinoma – a broad category with different morphologic features and heterogenous prognosis.
Highlights
BackgroundIn 2019, Trpkov and colleagues described an emerging entity among unclassified renal cell neoplasms
The term low-grade oncocytic tumour of kidney is an emerging entity describing CD117negative and cytokeratin 7-positive indolent tumors with overlapping morphological features between oncocytic tumors.Case presentation: We present the case of a 77-year-old female with a 3.2-cm nodule in mid pole of the left kidney
In 2019, Trpkov and colleagues described an emerging entity among unclassified renal cell neoplasms. They distinguished a new category of oncocytic tumors that do not fit in existing diagnostic entities (Trpkov et al 2019; Trpkov and Hes 2019)
Summary
In 2019, Trpkov and colleagues described an emerging entity among unclassified renal cell neoplasms. Abdominal magnetic resonance imaging showed a circumscribed solid tumour in the mid pole of the left kidney (Fig. 1a-b). It was a partially exophytic mass with central area suggestive of necrosis / hypovascularity. Oncocytic cells shared abundant eosinophilic cytoplasm and nuclei with occasional nucleoli (ISUP grades 1–2) without irregular contours such as “raisinoid”-shaped nuclei of chromophobe carcinomas. These solid areas showed common areas of transition to central zones of stromal edema with marked tumor hypocellularity and growth in
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
