Abstract
BackgroundMalignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva.Case presentationThe vulvar lesion was described as a mass measured 3.5 cm and located in the dermis and subcutis with no attachment to the epidermis. The neoplasm was arranged in ragged sheets or solid nodules sometimes with focal necrosis. The tumor cells had hyperchromatism, pleomorphism, and prominent nucleoli with high mitotic index and KI-67 estimated at 70–80%.ConclusionsIt’s only the fifth case of malignant eccrine spiradenoma localized at the vulva. This is the first time that an HPV genotyping was made in this type of lesion with no HPV found while the p16 expression was diffuse. Moreover, it’s the first time that a p53 mutation is detected by sequencing in this location.
Highlights
Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors
We describe a rare case of low grade Malignant eccrine spiradenoma (MES) located at the vulva not associated with Human Papilloma Virus (HPV) but with a p53 mutation
Direct transition from benign to malignant neoplasm was noted in approximately half of cases [7, 8]
Summary
Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva.Case presentation: The vulvar lesion was described as a mass measured 3.5 cm and located in the dermis and subcutis with no attachment to the epidermis. We describe a rare case of low grade MES located at the vulva not associated with Human Papilloma Virus (HPV) but with a p53 mutation. To the best of our knowledge, it’s only the fifth case of MES localized at the vulva [11,12,13,14] and this is the fisrts time that HPV genotyping was made with no HPV found.
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