Abstract
Phyllodes tumor (PT) of the breast is a rare disease usually presents as a large lump. The aim of this study was to report low grade malignant (borderline) PT of the breast in Kermanshah, Iran. A 55-year-old lady was admitted to the surgery ward with left breast mass since 2-3 months ago. In past medical history, the patient had left breast surgery due to fibrocystic change seven years ago. Grossly her specimen consisted in a piece of gray soft tissue measuring 10*8*4.5 cm with lobulated appearance and small cystic areas. In permanent diagnosis, the pathologist reported low-grade malignant (borderline) PT. Microscopically the tumor was composed of benign glandular elements and hypercellular spindle-shaped stroma. Mitotic index was 3/10 high power field (HPF). The border was well-circumscribed with satellite lesion. In conclusion, the diagnosis of borderline phyllodes tumor cannot be made only on age, the size of tumor, imaging or clinical features. Microscopic evaluation with evaluation of stromal cellularity, atypia, mitotic counts and border of the tumor is necessary for definite diagnosis and categorizing of this tumor.
Highlights
Phyllodes tumors (PTs) have an incidence of 1 per 100,000 women and account for only 0.5% of all breast malignancies [1]
PTs were more frequently situated in left breast than in the right side (58% vs. 42% respectively)
This study reported a 55-year-old lady with low-grade malignant PT of the left breast without axillary node involvement with a tumor size of 10 cm and mitotic index of 3/10HPF that the tumor was well circumscribed with cystic areas
Summary
Phyllodes tumors (PTs) have an incidence of 1 per 100,000 women and account for only 0.5% of all breast malignancies [1]. PT of the breast is a rare disease usually presents as a large lump. In few cases, it is bilateral or multifocal [2,3]. It is bilateral or multifocal [2,3] These neoplasms generally present as unilateral painless, well-circumscribed, mobile breast masses in women 35 to 55 years old [4]. Most PTs are benign (63–78%), with borderline PTs diagnosed in only 11–30% cases [6]. They are more prevalent in the Latin American, White and Asian populations [7].
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