Abstract
Fibrosarcoma is a malignant tumor of fibroblasts, which affects the head and neck region in 10% of cases. A 17-year-old woman sought treatment at an oral pathology center presenting a tumor-like lesion within the angle of the mandible with a time-course evolution of 10 months. The clinical and radiologic examination revealed expansive radiolucent lesion with bone cortical rupture. The tomographic examination revealed a hypodense image involving submandibular region and mandibular body. An incisional biopsy was performed. Histopathologic examination revealed fusiform cells with areas of mitosis and little pleomorphism. Immunohistochemistry was performed with results of low Ki67, positive vimetin, negative S100, negative HHF35, negative CD31, and negative β-catenin, concluding diagnosis of low grade fibrosarcoma. The patient went through surgical excision with a wide margin of safety, and after 1 year of clinical follow-up there were no signs of lesion recurrence.
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