Abstract
BackgroundLow-grade extraskeletal osteosarcomas (ESOS) are extremely rare.Case presentationWe present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man. Because of initial misdiagnosis and patient's refusal of surgery, the diagnosis was done after a 4-year history of a slowly growing mass in soft tissues, leading to a huge (30-cm diameter) calcified mass locally extended over the left chest wall. Final diagnosis was helped by molecular analysis of MDM2 and CDK4 oncogenes. Unfortunately, at this time, no surgical treatment was possible due to loco-regional extension, and despite chemotherapy, the patient died one year after diagnosis, five years after the first symptoms.ConclusionWe describe the clinical, radiological and bio-pathological features of this unique case, and review the literature concerning low-grade ESOS. Our case highlights the diagnostic difficulties for such very rare tumours and the interest of molecular analysis in ambiguous cases.
Highlights
Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare.Case presentation: We present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man
We describe a new case of lowgrade ESOS, which developed in the chest wall
Correct final diagnosis, suspected by the clinical evolution, was confirmed by molecular analysis, but was too late, and the patient died from extensive loco-regional progression
Summary
Our case is the seventh case of low-grade ESOS reported in literature, and the first case located in the chest wall It highlights the importance and difficulty of early diagnosis of this very rare tumour, which may be confused with numerous benign diseases, notably myositis ossificans. Author details 1Department of Medical Oncology, Institut Paoli-Calmettes, 13009 Marseille, France. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/10/645/prepub doi:10.1186/1471-2407-10-645 Cite this article as: Sabatier et al.: Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature.
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