Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature

Liang Wang,Di Zhang,En-Hua Wang,Xueshan Qiu,Qingchang Li,Xuyong Lin,Yang Liu

doi:10.1186/1746-1596-8-28

Abstract

Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior. This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern. Considering the histological features of LGCCC, it should be distinguished with papillocystic variant of acinic cell carcinoma, conventional salivary duct carcinoma, cystadenocarcinoma, polymorphous low-grade adenocarcinoma, carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma. Herein, we presented two cases of LGCCC. One arose in the left parotid region in a 48-year-old male, and the other one arose in the right parotid gland in a 59-year-old female. For both cases, immunohistochemically, the luminal tumor cells showed diffuse expression of CK and S100; p63 and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells. Both patients were alive with no tumor recurrence or metastasis at follow-up.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2593621568999135

Highlights

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare neoplasm of salivary gland
LGCCC was originally denominated as low-grade salivary duct carcinoma (LGSDC) in order to distinguish with the conventional SDC
Based on the histological features, LGCCC should be distinguished with other common parotid tumors including papillocystic variant of acinic cell carcinoma (PCV-ACC), conventional SDC, cystadenocarcinoma, polymorphous low-grade adenocarcinoma (PLGA), carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma (MASC)

Summary

Background

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare neoplasm of salivary gland It was described as a variant of salivary duct carcinoma (SDC) by Delgado et al in 1996 [1]. Based on the histological features, LGCCC should be distinguished with other common parotid tumors including papillocystic variant of acinic cell carcinoma (PCV-ACC), conventional SDC, cystadenocarcinoma, polymorphous low-grade adenocarcinoma (PLGA), carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma (MASC). The tumor cells were uniform without significant cytologic and nuclear atypia They displayed round to oval nuclei with fine chromatin and prominent nucleoli and pale to amphophilic cytoplasm. They displayed round to oval nuclei with fine chromatin and pale to amphophilic cytoplasm (Figure 1G).

Discussion

37 Current case 59 F

Findings

Conclusion