Low-Grade Chondrosarcoma Mimicking Chondroid Chordoma: A Case Report

Abstract

Chondrosarcomas and Chordomas account for the majority of primary skull base tumors, which are slow growing and locally aggressive. These tumors cause severe cranial nerve neuropathies. Both these tumors have similar clinical, radiological, and histological resemblances. Histopathology, along with immunohistochemistry, helps to differentiate these tumors. We are presenting a case of 39year old female who came with double vision, squint, headache, and tingling sensation over the right side of the face. Examination and investigations concluded a skull base tumor near the cavernous sinus. Surgical resection of the lesion was done and sent for histopathology. Microscopy showed hyaline cartilaginous islands, myxoid matrix, and individual cells with vacuolated cytoplasm and ovoid nucleus. Immunohistochemistry showed positive for S100. Final diagnosis of low-grade Chondrosarcoma was made. Keywords: Chondrosarcoma, Skull base tumors, Chordoma, S100