Abstract
Spindle cell lipoma (SCL) and pleomorphic lipoma (PL) constitute a spectrum of lipomatous lesions with distinctive clinicopathologic features. Multiple variants of SCL/PL have been reported including fibrous, plexiform, vascular, pseudoangiomatous, low-fat/fat-free, and myxoid changes. Herein we present a case of a 1 cm submucosal nodular lesion excised from the buccal mucosa of a 55-year-old female patient with classic histopathologic and immunohistochemical features of “low-fat” SCL with prominent myxoid stroma that initially suggested soft-tissue myxomatous lesion other than SCL. The current case exhibited microscopically few adipocytes supported by exuberant myxoid stroma. Immunohistochemistry was positive for CD34, vimentin, CD10 (on the spindle cells and myxoid component), as well as for S100 (on adipocytes). The Ki-67 was <1%. Pan-cytokeratin (AE1/AE3), desmin, a-SMA, EMA, bcl-2, p53 and remarkably retinoblastoma protein (pRb), were negative. “Low-fat” myxoid SCL bear no significant clinical/prognostic, but they pose a diagnostic challenge to pathologists who may be unfamiliar with this variant.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
