Abstract
Deficiency of vitamin D is an important cause of osteosarcopenia. The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316 nm, 0.16 mW/cm2, 1,000 J/m2). we set a total of 4 groups (n = 8 per group); vitamin D-repletion without UV irradiation (Vit.D+UV−), vitamin D-repletion with UV irradiation (Vit.D+UV +), vitamin D-deficiency without UV irradiation, (Vit.D−UV−), and vitamin D-deficiency with UV irradiation (Vit.D−UV +). Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D−UV+ group as compared with Vit.D−UV− group. Trabecular bone mineral density on micro-CT was higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D−UV+ group than in Vit.D−UV− group. Grip strength and muscle mass were higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.
Highlights
Deficiency of vitamin D is an important cause of osteosarcopenia
The purpose of this study is to determine the minimal irradiance intensity and dose of short-range UV irradiation by LED (UV-LED) that would be effective in supplying sufficient levels of serum vitamin D, and to examine the effects of UV-LED with a determined irradiance and dose on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6)
Notable results were that the Tb.BMD was significantly higher in the vitamin D-deficiency + irradiation (265 ± 23 g/cm3) than vitamin D-deficiency − irradiation (227 ± 27 g/cm3) group
Summary
The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Osteosarcopenia is a novel concept denoting the co-existence of decreased density of both bone and muscle, namely osteoporosis and sarcopenia[1,2] This condition promotes falls and insufficiency fractures that impede the activities of daily living (ADL) of elderly persons[3,4]. The purpose of this study is to determine the minimal irradiance intensity and dose of short-range UV-LED that would be effective in supplying sufficient levels of serum vitamin D, and to examine the effects of UV-LED with a determined irradiance and dose on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
