Abstract
Background: For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. Objective: We attempted to determine the efficacy of low-dose UVA 1 irradiation in patients with severe localized scleroderma. Methods: Patients were irradiated with 20 J/cm 2 UVA 1 for 12 weeks (total number of treatments: 30; cumulative UVA 1 dose: 600 J/cm 2). Results: Low-dose UVA 1 irradiation induced significant clinical improvement (clearance of>80% of lesions) in 18 of 20 patients. Clearance was documented by clinical score as well as by 20 MHz ultrasound and histopathologic analysis. Conclusion: Low-dose UVA 1phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy. (J Am Acad Dermatol 1998;38:21-6.)
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