Low-dose postoperative aprotinin reduces blood transfusion requirements in primary CABG patients on aspirin

Abstract

treatment group and 1.29kO.18 in the placebo group p=O.OOl). No significant differences were seen in cardiac (p=O.17). Troponin I levels at 4 hours postoperatively index, or LVSWI between treatment groups. were 60.7k22.3 in the treatment group and 100.0&4.1 in Conclusions: CoQlo serum levels can be raised the placebo group (p=O.42). No differences were seen in significantly with 1 week of oral dosing. No effect of recovery of peak developed force after ischaemic stress CoQlO is seen on early postoperative recovery in this in muscle strips from treated and untreated patients in initial cohort of patients. lschaemia did not sufficiently this initial cohort of patients. Hypoxia resulted in a depress recovery of muscle strips to detect any treatment significant decrease in recovery of peak developed force differences. Hypoxia with pacing has been successful in in untreated muscle strips compared with the untreated reducing recovery of developed force and will be used in ischaemic muscle strips (47.8%*10.8% vs 85.6%&4.5%, the second cohort of patients.