Low dose contrast medium combined with low dose gemstone CT perfusion versus enhanced imaging in differential diagnosis of solitary pulmonary nodules

Abstract

Objective To explore the values of low concentration contrast agent combined with low dose gemstone CT perfusion and enhanced imaging in the differential diagnosis of solitary pulmonary nodules (SPN). Methods 38 patients with benign SPN and 62 patients with milignant SPN were confirmed by puncture or surgical pathology. All patients underwent CT perfusion and enhanced imaging with low-contrast contrast agent and low-dose gemstone. The blood flow (BF ), blood volume (BV), surface permeability (PS), mean transit time (MTT), and nodule enhancement peak (PH) were measured. The diagnostic efficacy of ROC curve was analyzed. Results There were statistical differences in BV and PS between benign and malignant SPN (P 0.05). The PH values of benign and malignant SPNs were significantly different (P <0.05). The sensitivity, specificity, and specificity of BV in the diagnosis of malignant SPN were 85.3%, 60.3%, 80.6%, and 66.5%, respectively; those of PS were 88.1%, 66.5%, 85.8%, and 76.8%, respectively; and those of S/A were 82.9%, 87.0%, 83.8%, and 86.5%, respectively; and those of cooperative detection were 92.3%, 89.0%, 89.8%, and 90.5%, respectively. Conclusions CT perfusion and enhanced imaging of low-dose contrast agent combined with low-dose gemstone have high diagnostic efficacy in the differential diagnosis of benign and malignant SPN. Key words: Solitary pulmonary nodules; CT perfusion imaging; Benign and malignant