Abstract
Purpose:To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI).Materials & methods:Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion.Results:Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70).Conclusion:These results suggest promising protective pathway of colchicine after AMI.
Highlights
I/R was induced in C57BL/6J male mice by temporary left coronary artery was ligated and 400 μg/kg of colchicine or the placebo was administrated before the reperfusion
We evaluated the serum NGF concentration after Acute myocardial infarction (AMI)
The increases NGF circulating level after AMI suggests a stimulation in neuronal growth to compensate for the denervation in the myocardium. Colchicine prevented this NGF blood level increase, likely due to a lower neuronal death. This is the golden age of anti-inflammatory therapies in myocardial infarction and atherosclerosis
Summary
The objective of this study was to evaluate the impact of colchicine on heart rate variability (HRV) and cardiac sympathetic neuron remodeling in a mouse model of AMI
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