Abstract
The effect of low-dose clonazepam (CZP) on 24-hour long-term EEG recordings in 15 children with epilepsy was evaluated at the Karolinska Hospital, Stockholm, Sweden.
Highlights
Recordings in 15 children with epilepsy was evaluated at the Karolinska Hospital, Stockholm, Sweden
A single IM injection of 0.02 mg/kg/bwt produced a highly significant decrease in epileptiform activity compared to placebo, in a doubleblind study
Median plasma concentrations of CZP ranged from 18-
Summary
High-dose corticosteroid therapy, administered early at the first appearance of symptoms, has been recommended in previous reports LOW-DOSE CLONAZEPAM EFFECT ON EPILEPTIFORM ACTIVITY The effect of low-dose clonazepam (CZP) on 24-hour long-term EEG Recordings in 15 children with epilepsy was evaluated at the Karolinska Hospital, Stockholm, Sweden. A single IM injection of 0.02 mg/kg/bwt produced a highly significant decrease in epileptiform activity compared to placebo, in a doubleblind study.
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