Abstract
Preeclampsia (PE) is a serious pregnancy-related disease, and patients usually present with a high inflammatory response. Previous studies have suggested that aspirin (ASP) may have a role in alleviating the pathogenesis of preeclampsia. However, whether ASP can improve kidney damage and the mechanism for improving it is currently unclear. Here we optimized a lipopolysaccharide (LPS)-induced PE mouse model to identify the role of ASP in renal protection. We found that ASP treatment ameliorated LPS-induced renal failure and pathological changes, the tubular injury was significantly attenuated by ASP. Administration of ASP decreased the renal expression of pro-inflammatory factors, resulting in reduced kidney inflammation. The number of GALECTIN-3-positive cells was reduced, and the up-regulation of IL-6 and TNF-α was decreased. In addition, ASP also suppressed renal cell apoptosis and oxidative stress. An in vitro study indicated that ASP relieved LPS-induced HK-2 cell damage by inhibiting WNT5A/NF-κB signaling. Collectively, our data suggest that ASP is a useful therapeutic option for PE-related kidney injury.
Highlights
Preeclampsia (PE) is a serious pregnancy-related disorder and a leading cause of fetal and maternal morbidity and mortality [1, 2]
The results indicated a significant increase in blood pressure in the LPS-treated group, and this increase was evident after 5 days (E12.5) of LPS injection
LPSinduced hypertension was prevented by co-treatment with ASP, suggesting that the LPS-induced increase in blood pressure was related to inflammatory pathway activation
Summary
Preeclampsia (PE) is a serious pregnancy-related disorder and a leading cause of fetal and maternal morbidity and mortality [1, 2]. This multisystem disorder is characterized by new-onset hypertension, proteinuria, and inflammation, and generally appears after the 20th week of gestation [3, 4]. Inflammatory cytokines are major influencing factors of the kidneys during pathological pregnancy, which mainly lead to swollen glomeruli, fibrin deposits, and capillary occlusion [6, 7]. Reducing the production of pro-inflammatory factors and suppressing downstream signaling may constitute an Aspirin Prevents Preeclampsia-Related Kidney Damage effective approach to treat pregnancy-related kidney injury. How inflammatory signaling can be regulated in PErelated kidney damage is currently unknown
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