Low Dose Aspirin in Preeclampsia – History Revisited

Abstract

Objectives: To study the role of low-dose aspirin in prevention of pre-eclampsia .and its effect on maternal & neonatal outcome. DESIGN: A prospective randomized double-blind placebo controlled study. METHODS: All the high risk antenatal women presenting between 12–24 weeks of gestation were randomized to receive either aspirin 75 mg/day or matching placebo. Both the groups were compared for pre-eclampsia, pregnancy duration, birthweight, adverse maternal or neonatal outcome. RESULTS: A total of 120 women were followed up. The incidence of pre-eclampsia in aspirin group was 0.83% ,whereas none of the patients developed preeclampsia in placebo group. There were no significant differences between both the groups in. number of preterm delivery 11.47% in aspirin group vs 22% in placebo group, of SGA babies 16.9% vs 17.2% in placebo group. Aspirin was also not associated with increased risk of maternal or fetal complications. CONCLUSIONS: : The results of present study do not support the use of low dose aspirin for prevention of pre-eclampsia or its complications in any category of high risk women as proven by results of previous large scale trials and further multicentric large trials are still required to assess the role.