Low-dose Aspirin for the Prevention of Preterm Delivery in Nulliparous Women With a Singleton Pregnancy (ASPIRIN): A Randomized, Double-blind, Placebo-controlled Trial

Abstract

(Lancet. 2020;395:285–293) Preterm birth is a common cause of infant morbidity and mortality, especially in low- and middle-income countries with limited resources. Previous studies of aspirin used to prevent preeclampsia also suggested that low-dose aspirin may help lower the incidence of preterm births. However, no large-scale trial has specifically evaluated the use of low-dose aspirin initiated in early pregnancy with the primary purpose of preventing preterm birth. The aim of this study (the ASPIRIN trial) was to determine if low-dose aspirin administered daily starting in early pregnancy reduced the incidence of preterm delivery.