Abstract
BackgroundSince the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies.MethodsThis study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded.ResultsLDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24–0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29–0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55–1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35–2.26).ConclusionsTreatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage.Trial registrationChinese Clinical Trial Registry (ChiCTR); ChiCTR-OOC-16008203, Retrospectively registered date: April 1st, 2016;
Highlights
Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies
Pregnant women with twins who ‘booked’ in the First Affiliated Hospital of Chongqing Medical University were routinely offered prophylaxis with low-dose aspirin (LDA group) before 16 weeks of gestational age and those recruited from Chongqing Health Center for Women and Children were not required to take aspirin and regarded as controls (NC group)
In the LDA group, spontaneous conception occurred in 181 cases (65.3%), which was higher than the control group (n = 242; 36.9%, p < 0.001)
Summary
Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Twin pregnancies are associated with increased maternal and perinatal mortality and morbidity, and associated perinatal adverse outcomes, including preeclampsia (PE), small for gestational age (SGA) babies, and preterm birth (PTB) [1]. It has been reiterated that the incidence of PE in twin pregnancies is 3–4 times higher compared to singletons [2]. Ye et al BMC Pregnancy and Childbirth (2021) 21:786 pregnancies demonstrated the incidence of at least one twin with birthweight
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