Low Cord Serum Albumin is A Risk Indicator in Predicting Neonatal Jaundice.

Abstract

Objective: 1.Measuring the Cord Serum Albumin level (CSA) in predicting neonatal hyperbilirubinemia. Method: Prospective study was performed on 100 healthy term neonates. Relevant maternal history is collected. Cord blood was collected from the healthy term neonates at birth, CSA measured. Neonate was assessed clinically every day. Total Serum Bilirubin (TSB) and blood group were assessed in neonate during 7296 hours of life. TSB value ≥15mg/dl is considered Neonatal Hyperbilirubinemia (NH) which requires intervention like phototherapy (PT) or Exchange transfusion (ExT). Result: Study cohort is grouped in Group 1, Group 2 and Group 3 based on Cord Serum Albumin level ≤2.8g/dl, 2.9-3.3g/dl and ≥3.4g/dl, respectively. Statistical analysis was done for correlation of CSA with NH. It showed that cord serum albumin level ≤2.8g/dl is critical, as it was seen in 90% of neonates who developed neonatal hyperbilirubinemia. Conclusion: There is a correlation between Cord serum albumin level and neonatal hyperbilirubinemia. Cord serum albumin level of ≤2.8 g/dl is a risk indicator in predicting the development of neonatal hyperbilirubinemia at birth.