Low-contrast multifocal visual evoked potentials

Abstract

For 40 years, visual evoked cortical potentials (VEPs) have been used to aid in the diagnosis of demyelinating optic neuropathy.1 Early studies demonstrated an increased latency of the positive peak normally seen at about 100 msec—the P100—in patients with optic neuritis.1 Since the P100 often remains prolonged following recovery from the acute episode, the VEP is useful to detect optic nerve involvement in patients with suspected multiple sclerosis (MS).2 One might posit that the VEP would be useful in the identification of subclinical optic neuropathy, in which the demyelination is so …