Abstract
The concentration-dependence of the effect of muscarine on M-current ( I M) and the underlying M-conductance ( g M) in B-cells of bullfrog sympathetic ganglion was examined using whole-cell recording techniques. High concentrations of muscarine (≥200 nM) produced the classical suppression and over-recovery of steady-state I M at −30 mV. By contrast, low concentrations of muscarine (≤30 nM) shifted the g M activation curve to more negative potentials, increased the activation time constant ( τ a) and increased steady-state I M. This effect may reflect muscarine-induced changes in submembrane Ca 2+ concentration.
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